| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6022580 | Neurobiology of Disease | 2012 | 14 Pages |
Abstract
⺠The first rat model for DYT1 dystonia. ⺠Replication of key features of the disease including synaptic plasticity and nuclear envelope pathology. ⺠Expression of the protein under the control of the endogenous human promoter and its regulatory elements.
Keywords
DYT1 dystoniaADCROISWMFOVMSNAMPARMPDOPACLFSHFStorsinADWI3,4-dihydroxy-phenylacetic acidEPSPMovement disorderα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acidlong term depressionradial diffusivityhigh frequency stimulationlow frequency stimulationlong term potentiationLTPDopamineapparent diffusion coefficientCoefficient of VariationMotor cortexSubcortical white matterLTDTransgenic rat modelField of viewfractional anisotropyDopamine receptor type 2dopamine receptor type 1AIRresting membrane potentialexcitatory postsynaptic potentials
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Authors
Kathrin Grundmann, Nicola Glöckle, Giuseppina Martella, Giuseppe Sciamanna, Till-Karsten Hauser, Libo Yu, Salvador Castaneda, Bernd Pichler, Birgit Fehrenbacher, Martin Schaller, Brigitte Nuscher, Christian Haass, Jasmin Hettich, Zhenyu Yue,