| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6022599 | Neurobiology of Disease | 2012 | 11 Pages |
Abstract
⺠Inhibition of the HDAC3 subtype is necessary for amelioration of gene expression deficits related to HD. ⺠Rescue of neurodegeneration in HD flies can be achieved by treating with compounds that target class I HDACs. ⺠Amelioration of Htt-elicited metabolic deficits in striatal cells is correlated with potency of HDAC3 and HDAC1 inhibition. ⺠HDAC1 and HDAC3 accumulate in the nucleus of HD transgenic mice. ⺠HDAC1 and HDAC3 contribute to a repressive chromatin environment in HD.
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Authors
Haiqun Jia, Judit Pallos, Vincent Jacques, Alice Lau, Bin Tang, Andrew Cooper, Adeela Syed, Judith Purcell, Yi Chen, Shefali Sharma, Gavin R. Sangrey, Shayna B. Darnell, Heather Plasterer, Ghazaleh Sadri-Vakili, Joel M. Gottesfeld, Leslie M. Thompson,