| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6022614 | Neurobiology of Disease | 2012 | 10 Pages |
Abstract
⺠Ischemic-reperfusion injury increases expression of Txnip protein in mice. ⺠Txnip can be induced in neurons by oxidative stress without the presence of glucose. ⺠Txnip and other gene profiles are altered by oxidative stress or glucose. ⺠Induction of Txnip is mediated by calcium in an OGD and reoxygenation model. ⺠Down-regulation of Txnip by siRNA is neuroprotective after OGD stimulus.
Keywords
SOD3TXNIPTrx2-aminoethoxydiphenyl borate2-APB3-NPGAPDHTBSSTZOGD3-nitropropionic acidMPONOxSmall interfering RNAROSsiRNAstreptozotocinNADPH oxidaseTris-buffered salinethioredoxinlactate dehydrogenaseLDHoxygen–glucose deprivationmyeloperoxidasepolymerase chain reactionPCRthioredoxin-interacting proteinglyceraldehyde 3-phosphate dehydrogenaseReactive oxygen species
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Authors
Gab Seok Kim, Joo Eun Jung, Purnima Narasimhan, Hiroyuki Sakata, Pak H. Chan,