| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6022618 | Neurobiology of Disease | 2012 | 13 Pages |
Abstract
⺠It is unknown if Atrogin is associated with sarcopenia in human myositis disorders. ⺠Aβ expression and autoimmune inflammation independently result in Foxo3A nuclear translocation and Atrogin-1 induction. ⺠Aβi accumulation and cellular immune activation may drive atrophy in sIBM and PM, respectively, or synergistically in sIBM. ⺠In either disorder, efforts to limit Foxo3A activation may be therapeutic.
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Authors
Han-Kyu Lee, Edward Rocnik, Qinghao Fu, Bumsup Kwon, Ling Zeng, Kenneth Walsh, Henry Querfurth,