| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6022641 | Neurobiology of Disease | 2012 | 10 Pages |
Abstract
⺠A new mouse model of GLUT-1 deficiency allowed for electrophysiological and metabolic analysis. ⺠Thalamocortical oscillations are potentially relevant to the epileptic phenotype of GLUT-1 deficiency. ⺠Aerobic energy metabolism related to the Krebs cycle is intact in the mouse model, in contrast with enhanced lipid metabolism. ⺠Thus, we contest the contention that decreased brain glucose transport causes energy failure.
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Authors
Isaac Marin-Valencia, Levi B. Good, Qian Ma, Joao Duarte, Teodoro Bottiglieri, Christopher M. Sinton, Charles W. Heilig, Juan M. Pascual,