Activation of the Î³-secretase complex and presence of Î³-secretase-activating protein may contribute to AÎ²42 production in sporadic inclusion-body myositis muscle fibers

Article ID	Journal	Published Year	Pages	File Type
6022651	Neurobiology of Disease	2012	9 Pages	PDF

Abstract

âº Î³-secretase components, presenilin1, Pen2, and nicastrin, are increased in s-IBM muscle. âº Î³-secretase activity is increased in s-IBM muscle fibers. âº A novel Î³-secretase activating protein (GSAP) is present in s-IBM muscle fibers. âº In cultured human muscle, autophagy inhibition increases Î³-secretase activity. âº Experimentally inhibited autophagy leads to increase of AÎ²42.

Keywords

BACE1 Aβ AβPP Aph-1 EPOX amyloid-β cultured human muscle fibers Epoxomicin Alzheimer disease amyloid-β precursor protein Chlor Chloroquine