| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6022654 | Neurobiology of Disease | 2012 | 8 Pages |
Abstract
⺠Compelling new evidence for toxic channel mechanism of cell injury in ALS. ⺠A4V mutant was studied using complementary techniques. ⺠High resolution AFM revealed tetrameric pore structures in lipid bilayers. ⺠Heterogeneous single channel conductance was observed in lipid bilayers. ⺠Plasma membrane depolarization and cell calcium loading were observed in N2A cells.
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Authors
Michael J. Allen, Jérome J. Lacroix, Srinivasan Ramachandran, Ricardo Capone, Jenny L. Whitlock, Ghanashyam D. Ghadge, Morton F. Arnsdorf, Raymond P. Roos, Ratnesh Lal,