| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6022670 | Neurobiology of Disease | 2012 | 9 Pages |
Abstract
⺠Iron is trapped in heat and SDS-stable protein complexes in sCJD brains. ⺠This causes iron deficiency that correlates with PrPSc. ⺠Iron may be trapped in PrPSc-ferritin complexes in an intracellular compartment. ⺠PrPSc and ferritin do not co-aggregate in a PMCA reaction. ⺠PrPSc-protein complexes formed in vivo differ from PrPSc generated by PMCA.
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Authors
Ajay Singh, Liuting Qing, Qingzhong Kong, Neena Singh,