| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6022690 | Neurobiology of Disease | 2012 | 11 Pages |
Abstract
⺠Early exposure to general anesthesia impairs the immature neuronal mitochondria. ⺠Anesthesia causes free oxygen radical upregulation and lipid peroxidation. ⺠EUK-134 and R(+) pramipexole down regulate ROS and protect mitochondria. ⺠EUK-134 and R(+) pramipexole prevent anesthesia-induced cognitive impairments.
Keywords
LD50PNDPramipexoleKOHCA1BHTs.c.N2OH2-DCF-DAEUK-134PPXi.p.PBSOFTDMSODNAMn-SODROSAdenosine tri-phosphateATPOpen field testcornu ammonis area 1EDTAdeoxyribonucleic acidNitrous oxideIsofluraneenzyme immunoassayEIAGeneral anesthesiaELISAEnzyme-linked immunosorbent assayintra-peritonealDimethyl sulfoxideRampost-natal daysubcutaneousPhosphate buffered salinemanganese-superoxide dismutasemedian lethal dosebutylated hydroxytoluenePotassium HydroxideLipid peroxidationRadial arm mazeReactive oxygen speciesLearning/memory
Related Topics
Life Sciences
Neuroscience
Neurology
Authors
A. Boscolo, J.A. Starr, V. Sanchez, N. Lunardi, M.R. DiGruccio, C. Ori, A. Erisir, P. Trimmer, J. Bennett, V. Jevtovic-Todorovic,