Metabotropic glutamate receptor-dependent long-term depression is impaired due to elevated ERK signaling in the ÎRG mouse model of tuberous sclerosis complex

Article ID	Journal	Published Year	Pages	File Type
6022701	Neurobiology of Disease	2012	10 Pages	PDF

Abstract

âº Mutations in TSC2-GAP domain disrupt hippocampal mGluR-LTD in ÎRG mice. âº ÎRG mice exhibit normal mTORC1 signaling, but enhanced ERK signaling. âº Impaired hippocampal mGluR-LTD is due to aberrant MEK/ERK signaling in ÎRG mice. âº Mice with conditional deletions of the Tsc1 and Tsc2 genes exhibit deficits in mGluR-LTD, but normal MEK/ERK signaling.

Keywords

FXS RHEB eIF4E binding protein 4E-BP mTORC1 GTP aCSF GDP fragile X syndrome cytomegalovirus CMV GAP artificial cerebrospinal fluid Mammalian target of rapamycin complex 1 GTPase-activating protein Guanosine triphosphate guanosine diphosphate

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Metabotropic glutamate receptor-dependent long-term depression is impaired due to elevated ERK signaling in the ÎRG mouse model of tuberous sclerosis complex

Authors

Itzamarie Chévere-Torres, Hanoch Kaphzan, Aditi Bhattacharya, Areum Kang, Jordan M. Maki, Michael J. Gambello, Jack L. Arbiser, Emanuela Santini, Eric Klann,