| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6022707 | Neurobiology of Disease | 2012 | 9 Pages |
Abstract
⺠Gliosis is the dominant change of the cerebellar transcriptome upon ERCC1 deficiency. ⺠No transcriptome evidence of Purkinje cell degeneration in the ERCC1-deficient brain. ⺠Forebrain transcripts of cholesterol biosynthesis genes decline upon ERCC1 deficiency. ⺠Defects in DNA repair may reduce cholesterol biosynthesis in the brain.
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Authors
Scott C. Smith, Andria R. Robinson, Laura J. Niedernhofer, Michal Hetman,