Lithium reverses increased rates of cerebral protein synthesis in a mouse model of fragile X syndrome

Article ID	Journal	Published Year	Pages	File Type
6022710	Neurobiology of Disease	2012	8 Pages	PDF

Abstract

âº Chronic lithium reverses increased cerebral protein synthesis in Fmr1 KO mice âº Chronic lithium has little effect on cerebral protein synthesis in WT mice âº PI3K/Akt pathway signaling does not fully account for effects on hippocampal rCPS âº MAPK/ERK 1/2 pathway signaling does not fully account for effects on hippocampal rCPS

Keywords

4E-BP1 PI3K Fmr1 MAPK/ERK1/2 FXS mTOR ERK FMRP RCPs p70 S6K p70 S6 kinase Lithium PI3K/AKT Akt Protein synthesis fragile X syndrome Phosphatidylinositol 3-kinase Brain Mouse knock out wild type mammalian target of rapamycin Hippocampus Pike eIF4E-binding protein fragile X mental retardation protein protein kinase B extracellular-signal-regulated kinase