| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6022730 | Neurobiology of Disease | 2011 | 14 Pages |
Abstract
⺠In this paper we show that the hematopoietic cytokine, granulocyte macrophage colony stimulating factor (GM-CSF), had neuroprotective effects in a toxin based model of Parkinson's disease. ⺠Because GM-CSF was effective when given systemically as well as centrally, it might hold particular clinical promise. ⺠GM-CSF might act by “normalizing” inflammatory glial cells and promoting trophic support to dopamine neurons following bacterial or chemical toxin exposure.
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Authors
E.N. Mangano, S. Peters, D. Litteljohn, R. So, C. Bethune, J. Bobyn, M. Clarke, S. Hayley,