| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6022736 | Neurobiology of Disease | 2011 | 8 Pages |
Abstract
⺠Invertebrate models suggest dystrophins retrogradely regulate transmitter release. ⺠We examined brain excitatory presynaptic ultrastructure in mice lacking Dp427 or Dp71. ⺠Dp427 loss increases number of docked vesicles and reduces undocked vesicle size. ⺠Dp71 loss alters vesicles pool organization, vesicle size and synaptic cleft width. ⺠Presynaptic alterations may contribute to cognitive deficits in muscular dystrophy.
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Authors
Rubén Miranda, Uri Nudel, Serge Laroche, Cyrille Vaillend,