| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6022738 | Neurobiology of Disease | 2011 | 10 Pages |
Abstract
⺠In this study we characterized the SMN2 transgenic mouse, Tg(SMN2)89Ahmb. It is the most commonly used SMN2 transgene in mouse models of spinal muscular atrophy. ⺠Tg(SMN2)89Ahmb integrated within the metabatropic glutamate receptor 7 (mGluR7)gene and created a hypomorphic allele. ⺠On a hybrid FVB/N background (70% FVB/N) this causes increased seizure susceptibility and a heightened fear response.
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Authors
Rocky G. Gogliotti, Cathleen Lutz, Michael Jorgensen, Kimberly Huebsch, Sookyong Koh, Christine J. DiDonato,