Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6022748 | Neurobiology of Disease | 2011 | 11 Pages |
Abstract
⺠During neuronal maturation, nuclear and nucleolar chromatin changes are observed. ⺠Neuronal chromatin is globally altered as a result of MeCP2 deficiency. ⺠Neuronal nucleolar enlargement in early postnatal life requires MeCP2. ⺠Activity-induced changes to neuronal heterochromatic chromocenters require MeCP2. ⺠A Rett MBD mutation affects nucleolar enlargement during neuronal maturation.
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Authors
Malaika K. Singleton, Michael L. Gonzales, Karen N. Leung, Dag H. Yasui, Diane I. Schroeder, Keith Dunaway, Janine M. LaSalle,