| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6022750 | Neurobiology of Disease | 2011 | 12 Pages |
Abstract
⺠Rat model of aging exhibits impaired spatial learning and memory similar to humans. ⺠Plasticity-associated proteins are dysregulated specifically with cognitive decline. ⺠Expression of plasticity-mediating proteins correlates with cognitive performance. ⺠Cognition-specific changes occur in conjunction with age-related alterations. ⺠Dysregulation occurs throughout the hippocampal formation.
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Authors
Heather D. VanGuilder, Julie A. Farley, Han Yan, Colleen A. Van Kirk, Matthew Mitschelen, William E. Sonntag, Willard M. Freeman,