| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6022764 | Neurobiology of Disease | 2011 | 9 Pages |
Abstract
⺠Intralaminar thalamic neurons play a crucial role for absence seizures in generalized epilepsy. ⺠Their electrical activity is locked to spike-wave discharges through GABAergic synaptic influences. ⺠Consequences are rhythmic inhibition of tonic firing or delayed burst firing, depending on thalamic area. ⺠This likely increases synchronization in thalamo-cortical circuits and impacts cognitive function.
Keywords
NRTSWDsSpike-and-wave dischargesGATGAERSIPSPsECoGWAG/Rijγ aminobutyric acidElectroencephalogramelectrocorticogramseizureGABA transporterGenetic Absence Epilepsy Rats from StrasbourgGenetic modelEEGNeuronal oscillationreticular thalamic nucleuscentrolateral thalamic nucleusparacentral thalamic nucleusinhibitory postsynaptic potentialsGABA
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Authors
Ali Gorji, Christoph Mittag, Parviz Shahabi, Thomas Seidenbecher, Hans-Christian Pape,