| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6022766 | Neurobiology of Disease | 2011 | 10 Pages |
Abstract
⺠Painful diabetic neuropathy induces neuronal hyperactivity at spinal cord and PAG. ⺠Serotonin and noradrenaline levels are increased at spinal cord of STZ-diabetic rats. ⺠Serotoninergic and noradrenergic brainstem neurons are hyperactivated during diabetes ⺠IGF1 inhibits spinal cord and PAG neuronal hyperactivation during diabetes. ⺠IGF1 prevents the monoamine changes in pain control system during diabetes.
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Authors
Carla Morgado, Liliana Silva, PatrÃcia Pereira-Terra, Isaura Tavares,