PDE10A and PDE10A-dependent cAMP catabolism are dysregulated oppositely in striatum and nucleus accumbens after lesion of midbrain dopamine neurons in rat: A key step in parkinsonism physiopathology

Article ID	Journal	Published Year	Pages	File Type
6022770	Neurobiology of Disease	2011	11 Pages	PDF

Abstract

âº Dopamine loss up- or down-regulates PDE10A respectively in n. accumbens and striatum. âº cAMP is up-regulated in striatum but down-regulated in n. accumbens by dopamine loss. âº cGMP is down-regulated both in the striatum and n. accumbens by dopamine loss. âº PDE10A up- and down-regulation parallels cAMP but not cGMP altered by dopamine loss.

Keywords

cGMP PDE MSN PDE10A adenosine 3′, 5′-cyclic monophosphate cAMP guanosine 3′,5′-cyclic monophosphate phosphodiesterase 10A medium spiny neurons