Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6022770 | Neurobiology of Disease | 2011 | 11 Pages |
Abstract
⺠Dopamine loss up- or down-regulates PDE10A respectively in n. accumbens and striatum. ⺠cAMP is up-regulated in striatum but down-regulated in n. accumbens by dopamine loss. ⺠cGMP is down-regulated both in the striatum and n. accumbens by dopamine loss. ⺠PDE10A up- and down-regulation parallels cAMP but not cGMP altered by dopamine loss.
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Authors
M. Giorgi, G. Melchiorri, V. Nuccetelli, V. D'Angelo, A. Martorana, R. Sorge, V. Castelli, G. Bernardi, G. Sancesario,