LRRK2 kinase activity mediates toxic interactions between genetic mutation and oxidative stress in a Drosophila model: Suppression by curcumin

Article ID	Journal	Published Year	Pages	File Type
6022787	Neurobiology of Disease	2012	8 Pages	PDF

Abstract

âº H2O2 enhances LRRK2 kinase activity and toxicity. âº H2O2 augments LRRK2-induced locomotor defects and dopamine neuron loss in flies. âº GW5074 reduces the combined toxicity of H2O2 and LRRK2 mutation. âº Curcumin inhibits LRRK2 kinase activity and rescues PD-like phenotypes in flies.

Keywords

4E-BP ROC LRRK2 PAL ppm PAM ddC Parkinson disease Parkinson's disease Immunoprecipitation Gene–environment interaction leucine-rich repeat kinase 2 tyrosine hydroxylase Dopamine Drosophila dopamine neuron H2O2 Curcumin

Related Topics

Life Sciences Neuroscience Neurology

Preview

LRRK2 kinase activity mediates toxic interactions between genetic mutation and oxidative stress in a Drosophila model: Suppression by curcumin

Authors

Dejun Yang, Tianxia Li, Zhaohui Liu, Nicolas Arbez, Jianqun Yan, Timothy H. Moran, Christopher A. Ross, Wanli W. Smith,