| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6022794 | Neurobiology of Disease | 2012 | 8 Pages |
Abstract
⺠Diabetes mellitus targets sensory neurons prominently, in addition to autonomic and motor neurons. ⺠Intrinsic neuronal protective mechanisms may prevent manifestations of neuropathy. ⺠Overexpression of human HSP27 in peripheral neurons of mice prevented loss of sensory epidermal axons. ⺠Overexpression of human HSP27 also prevented changes in sensation and prevented sensory, but not motor conduction slowing. ⺠Overexpression of a single gene altered several unique abnormalities of sensory axons in diabetic neuropathy.
Related Topics
Life Sciences
Neuroscience
Neurology
Authors
L. Korngut, C.H.E. Ma, J.A. Martinez, C.C. Toth, G.F. Guo, V. Singh, C.J. Woolf, D.W. Zochodne,