| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6022812 | Neurobiology of Disease | 2010 | 14 Pages |
Abstract
⺠AMPA GluA1 knockout mice (KO) show depression- and schizophrenia-related behaviors. ⺠Here we tested GluA1 KO for mania-related abnormalities. ⺠KO showed manic-like behavior, including locomotor hyperactivity, in various tests. ⺠Lithium treatment normalized some of these behaviors and prefrontal abnormalities. ⺠GluA1 KO may provide a novel tool for studying schizoaffective disorder.
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Authors
Paul J. Fitzgerald, Chris Barkus, Michael Feyder, Lisa M. Wiedholz, Yi-Chyan Chen, Rose-Marie Karlsson, Rodrigo Machado-Vieira, Carolyn Graybeal, Trevor Sharp, Carlos Zarate, Judith Harvey-White, Jing Du, Rolf Sprengel, Peter Gass, David Bannerman,