| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6022831 | Neurobiology of Disease | 2011 | 10 Pages |
Abstract
⺠Clioquinol acts as a zinc ionophore and introduces zinc into autophagic vacuoles. ⺠Clioquinol induces autophagy in astrocytic cultures in a zinc-dependent manner. ⺠Autophagy induced by clioquinol reduces accumulation of huntingtin aggregates. ⺠Excessive clioquinol induces autophagic cell death especially in neurons. ⺠In conclusion, adequate doses of clioquinol may have beneficial actions in the Alzheimer's Diseases brains.
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Authors
Mi-Ha Park, Sook-Jeong Lee, Hyae-ran Byun, Yunha Kim, Young J. Oh, Jae-Young Koh, Jung Jin Hwang,