| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6022860 | Neurobiology of Disease | 2011 | 12 Pages |
Abstract
⺠shRNA SMN lentiviral transduction causes 70% SMN protein level reduction in cultured motoneurons. ⺠SMN protein reduction causes neurite degeneration, SMN and neurofilament accumulation in neurite “blebs”. ⺠SMN protein reduction causes late motoneuron cell death. ⺠Motoneuron degeneration caused by SMN knockdown can be rescued by Bcl-xL overexpression.
Keywords
GFPNTFHGFBcl-xLCT-1GDNFSMNmotoneuronCNTFshRNABDNFshort hairpin RNAspinal muscular atrophyempty vectorSMAHepatocyte growth factorbrain derived neurotrophic factorNeurotrophic factorGlial cell line-derived neurotrophic factorciliary neurotrophic factorNTFs, Neurotrophic factorssurvival motor neurongreen fluorescent proteincardiotrophin 1
Related Topics
Life Sciences
Neuroscience
Neurology
Authors
Ana Garcera, Stefka Mincheva, Myriam Gou-Fabregas, VÃctor Caraballo-Miralles, Jerònia Lladó, Joan X. Comella, Rosa M. Soler,