| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6022893 | Neurobiology of Disease | 2011 | 11 Pages |
Abstract
⺠[F-18]FDDNP microPET imaging in a transgenic rat model of Alzheimer's disease. ⺠β-amyloid (Aβ) levels correlate with [F-18]FDDNP signal and increase with age. ⺠[F-18]FDDNP labels both diffuse and fibrillar Aβ plaques. ⺠Naproxen pre-treatment reversibly blocks [F-18]FDDNP binding. ⺠Intracranial anti-Aβ antibody delivery decreases Aβ levels and [F-18]FDDNP signal.
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![[F-18]FDDNP microPET imaging correlates with brain Aβ burden in a transgenic rat model of Alzheimer disease: Effects of aging, in vivo blockade, and anti-Aβ antibody treatment](/preview/png/6022893.png "First Page Preview: [F-18]FDDNP microPET imaging correlates with brain Aβ burden in a transgenic rat model of Alzheimer disease: Effects of aging, in vivo blockade, and anti-Aβ antibody treatment")
Authors
Edmond Teng, Vladimir Kepe, Sally A. Frautschy, Jie Liu, Nagichettiar Satyamurthy, Fusheng Yang, Ping-Ping Chen, Graham B. Cole, Mychica R. Jones, Sung-Cheng Huang, Dorothy G. Flood, Stephen P. Trusko, Gary W. Small, Gregory M. Cole, Jorge R. Barrio,