Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6022893 | Neurobiology of Disease | 2011 | 11 Pages |
Abstract
⺠[F-18]FDDNP microPET imaging in a transgenic rat model of Alzheimer's disease. ⺠β-amyloid (Aβ) levels correlate with [F-18]FDDNP signal and increase with age. ⺠[F-18]FDDNP labels both diffuse and fibrillar Aβ plaques. ⺠Naproxen pre-treatment reversibly blocks [F-18]FDDNP binding. ⺠Intracranial anti-Aβ antibody delivery decreases Aβ levels and [F-18]FDDNP signal.
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Authors
Edmond Teng, Vladimir Kepe, Sally A. Frautschy, Jie Liu, Nagichettiar Satyamurthy, Fusheng Yang, Ping-Ping Chen, Graham B. Cole, Mychica R. Jones, Sung-Cheng Huang, Dorothy G. Flood, Stephen P. Trusko, Gary W. Small, Gregory M. Cole, Jorge R. Barrio,