| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6022903 | Neurobiology of Disease | 2011 | 7 Pages |
Abstract
⺠Loss of brain dystrophin alters GABAr clustering, plasticity and cognitive functions. ⺠Rescue of brain dystrophin by exon skipping restores GABAr clustering. ⺠We show that exon skipping normalizes synaptic plasticity in mice lacking dystrophin. ⺠Exon skipping may thus improve both muscle and brain defects in muscular dystrophy. ⺠Dystrophin may modulate synaptic plasticity through GABAr clustering in adult brain.
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Authors
Glenn Dallérac, Caroline Perronnet, Carine Chagneau, Pascale Leblanc-Veyrac, Nathalie Samson-Desvignes, Elise Peltekian, Olivier Danos, Luis Garcia, Serge Laroche, Jean-Marie Billard, Cyrille Vaillend,