Bcl2-A1 interacts with pro-caspase-3: Implications for amyotrophic lateral sclerosis

Article ID	Journal	Published Year	Pages	File Type
6022905	Neurobiology of Disease	2011	9 Pages	PDF

Abstract

âº ALS-linked mutant SOD1 induces Bcl2-A1 expression via the redox-sensitive AP1 transcription factor in motor neuronal cells. âº Bcl2-A1 can interact with pro-caspase-3, via its C-terminal helix Î±9. âº Bcl2-A1/pro-caspase-3 interaction can prevents the completion of caspase-3 processing in vitro. âº Bcl2-A1 lacking helix Î±9 has impaired anti-apoptotic activity in motor neuronal cells expressing ALS-linked mutant SOD1.

Keywords

NF-κB PBS SDS SOD1 GST NSC34 cells AP-1 amyotrophic lateral sclerosis ALS Mutant SOD1 Apoptosis sodium dodecyl sulfate superoxide dismutase 1 nuclear factor kappa-light-chain-enhancer of activated B cells Phosphate-buffered saline activator protein 1 glutathione S-transferase