| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6022906 | Neurobiology of Disease | 2011 | 12 Pages |
Abstract
⺠DJ-1 colocalizes with the synaptic vesicle proteins such as synaptophysin and Rab3A. ⺠Wild type DJ-1 protein directly binds membranes without an intermediary protein. ⺠The pathogenic L166P mutation of DJ-1 exhibits less binding to synaptic vesicles. ⺠The association between DJ-1 and synaptic vesicles may contribute to the pathomechanisms in PARK7-linked PD.
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Authors
Yukiko Usami, Taku Hatano, Satoshi Imai, Shin-ichiro Kubo, Shigeto Sato, Shinji Saiki, Yoichiro Fujioka, Yusuke Ohba, Fumiaki Sato, Manabu Funayama, Hiroto Eguchi, Kaori Shiba, Hiroyoshi Ariga, Jie Shen, Nobutaka Hattori,