Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6022912 | Neurobiology of Disease | 2011 | 8 Pages |
Abstract
⺠Mammalian Atg8 homologues containing LC3 and GABARAPs are involved in autophagosomal formation. ⺠We examined whether Atg8 homologues were altered in Lewy body disease. ⺠All Atg8 homologues were localized in Lewy bodies. ⺠LC3 was the most vulnerable protein among them. ⺠Autophagic function can be impaired through alteration of Atg8 homologues in Lewy body disease.
Related Topics
Life Sciences
Neuroscience
Neurology
Authors
Kunikazu Tanji, Fumiaki Mori, Akiyoshi Kakita, Hitoshi Takahashi, Koichi Wakabayashi,