| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6022949 | Neurobiology of Disease | 2010 | 16 Pages |
Abstract
Trehalose is neuroprotective in this model of tauopathy. Since trehalose is free of toxic effects at high concentrations, this study opens the way for clinical studies of the effects of trehalose in human tauopathies.
Keywords
HspDATPSPTauopathiesAutophagic vacuolesCBDAPPFTDGSHAβROSAutophagyParkinson's diseaseTrehalosesubstantia nigratyrosine hydroxylaseDopamine transportTauDopamineCorticobasal degenerationfrontotemporal dementiaProgressive supranuclear palsylipid dropletLysosomesLYSwild-typeParkinHeat shock proteinamyloid precursor proteinamyloid peptideCHiPGlutathioneReactive oxygen species
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Authors
Jose A. RodrÃguez-Navarro, Laura RodrÃguez, MarÃa J. Casarejos, Rosa M. Solano, Ana Gómez, Juan Perucho, Ana MarÃa Cuervo, Justo GarcÃa de Yébenes, MarÃa A. Mena,