Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6023005 | Neurobiology of Disease | 2009 | 10 Pages |
Abstract
In this study, we demonstrate that gamma oscillations (30-50 Hz) recorded in the local field potentials (LFP) of the hippocampus are a marker of temporal lobe seizure propagation and that the level of LFP synchrony in the amygdalo-hippocampal network, during these oscillations, is related to the severity of seizures. Sprague-Dawley rats were given a single systemic dose of kainic acid (KA; 6 mg/kg, i.p.) and local field potential activity (1-475 Hz) of the dorsal hippocampus, the amygdala and the neocortex was recorded. Of 135 ictal discharges, 55 (40.7%) involved both limbic structures. We demonstrated that 78.2% of seizures involving both the hippocampus and amygdala showed hippocampal gamma oscillations. Seizure duration was also significantly correlated with the frequency of hippocampal gamma oscillations (r2 = 0.31, p < 0.01) and LFP synchrony in the amygdalo-hippocampal network (r2 = 0.21, p < 0.05). These results suggest that gamma oscillations in the amygdalo-hippocampal network could facilitate long-range synchrony and participate in the propagation of seizures.
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Authors
Maxime Lévesque, J.M. Pierre Langlois, Pablo Lema, Richard Courtemanche, Guillaume-Alexandre Bilodeau, Lionel Carmant,