Fe3O4 Nanoparticles as an Efficient and Magnetically Recoverable Catalyst for the Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones under Solvent-Free Conditions

The catalytic activity of Fe3O4 nanoparticles (NPs) in a one-pot three component condensation reaction consisting of an aromatic aldehyde, urea or thiourea, and a β-dicarbonyl under solvent-free conditions was investigated. This reaction affords the corresponding dihydropyrimidinones (thiones) in high to excellent yields. Compared with the classical Biginelli reactions this method consistently gives a high yield, easy magnetic separation, a short reaction time, and catalyst reusability.

Graphical abstractThe catalytic activity of Fe3O4 nanoparticles (NPs) during the synthesis of dihydropyrimidinones under solvent-free conditions was investigated. The advantages of this method are a high yield, a short reaction time, easy magnetic separation, and catalyst reusability.Figure optionsDownload full-size imageDownload as PowerPoint slide