Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
602336 | Colloids and Surfaces B: Biointerfaces | 2009 | 6 Pages |
Abstract
This study demonstrates a method where contact angle goniometry combined with surface tension measurements is used to assess the interactions of drugs with the hydrophobic core of a biological membrane. To this end, self-assembled monolayers (SAMs) of two alkanethiol and one thiolipid on Au(1 1 1) surfaces are used as model membranes and their interaction with six β-blockers is studied. The Gibbs equation and the Langmuir adsorption isotherm are used to determine the partition coefficients for the adsorption of the drugs, which are compared to the octanol–water partition coefficients as well as the liposome–water partition coefficients. The ability of the different SAMs to serve as model membranes in partitioning of drugs is discussed.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Colloid and Surface Chemistry
Authors
Marjukka Ikonen, Lasse Murtomäki, Kyösti Kontturi,