Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6024708 | NeuroImage | 2015 | 44 Pages |
Abstract
Stability of oscillatory signatures across magnetoencephalography (MEG) measurements is an important prerequisite for basic and clinical research that has been insufficiently addressed. Here, we evaluated the test-retest reliability of auditory steady-state responses (ASSRs) over two MEG sessions. The study required participants (NÂ =Â 13) to detect the rare occurrence of pure tones interspersed within a stream of 5Â Hz or 40Â Hz amplitude-modulated (AM) tones. Intraclass correlations (ICC; Shrout and Fleiss, 1979) were derived to assess stability of spectral power changes and the inter-trial phase coherence (ITPC) of task-elicited neural responses. ASSRs source activity was estimated using eLORETA beamforming from bilateral auditory cortex. ASSRs to 40Â Hz AM stimuli evoked stronger power modulation and phase-locking than 5Â Hz stimulation. Overall, spectral power and ITPC values at both sensor- and source-level showed robust ICC values. Notably, ITPC measures yielded higher ICCs (~Â 0.86-0.96) between sessions compared to the assessment of spectral power change (~Â 0.61-0.82). Our data indicate that spectral modulations and phase consistency of ASSRs in MEG data are highly reproducible, providing support for MEG-measured oscillatory parameters in basic and clinical research.
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Authors
H.-R.M. Tan, J. Gross, P.J. Uhlhaas,