Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6024880 | NeuroImage | 2015 | 9 Pages |
Abstract
The acute SSRI response on inhibitory processes and attentional orienting interacts with genotypes regulating 5-HTT gene expression. SS subjects may show increased attentional side effects reflected in increases in P3a amplitudes which could contribute to treatment discontinuation. Inhibitory processes and their neural correlates are affected only in LL subjects. These findings may indicate an underlying mechanism that could relate genotypical differences to altered side effect profiles and drug responses and are compatible with a non-monotonic relationship between 5-HT levels and optimal functioning.
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Authors
Adrian G. Fischer, Tanja Endrass, Ingrid Goebel, Martin Reuter, Christian Montag, Christian Kubisch, Markus Ullsperger,