| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 602679 | Colloids and Surfaces B: Biointerfaces | 2007 | 8 Pages |
Abstract
DNA compaction, encapsulation and stabilization strategies as well as a scheme for DNA chain stabilization by complex formation with modified fullerenes for gene delivery are discussed. DNA can be compacted in organic solvents and encapsulated with amphiphilic triblock copolymers. The rapid removal of the solvent mixtures by electrospinning together with a biodegradable polymer preserves the globular DNA conformation and can be used for bone reconstruction applications. Cationic fullerene surfactants can decorate and stabilize DNA coils in aqueous solution. The complex formation process is studied by static light scattering and analyzed in detail.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Colloid and Surface Chemistry
Authors
Christian Burger, Benjamin Chu,