| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6027046 | NeuroImage | 2014 | 11 Pages |
Abstract
[11C]GR103545 PET can be used to image and quantify KOR in humans, although it has slow kinetics and variability of model-derived kinetic parameters is higher than desirable. This tracer should be suitable for use in receptor occupancy studies, particularly those that target high occupancy.
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Cognitive Neuroscience
![Evaluation of the agonist PET radioligand [11C]GR103545 to image kappa opioid receptor in humans: Kinetic model selection, test-retest reproducibility and receptor occupancy by the antagonist PF-04455242](/preview/png/6027046.png "First Page Preview: Evaluation of the agonist PET radioligand [11C]GR103545 to image kappa opioid receptor in humans: Kinetic model selection, test-retest reproducibility and receptor occupancy by the antagonist PF-04455242")
Authors
Mika Naganawa, Leslie K. Jacobsen, Ming-Qiang Zheng, Shu-Fei Lin, Anindita Banerjee, Wonkyung Byon, David Weinzimmer, Giampaolo Tomasi, Nabeel Nabulsi, Sarah Grimwood, Lori L. Badura, Richard E. Carson, Timothy J. McCarthy, Yiyun Huang,