Article ID Journal Published Year Pages File Type
602737 Colloids and Surfaces B: Biointerfaces 2007 7 Pages PDF
Abstract

Poly(N-isopropylacrylamide) (PAAm) is a thermal responsive polymer that undergoes a structural change in aqueous solution at its lower critical solution temperature (LCST). PAAm-modified silicon substrates were prepared and the effect of PAAm density on the thermal response of the modified surface was examined in terms of changes in the water contact angle as a basis for applying the structural change of the polymer to controlled drug release. Changes with temperature in the ability to load and release of the modified layer for drug were also examined using 2-acetoxybenzoic acid (aspirin) as a model drug. The amount of PAAm was found to greatly affect the thermal response and the ability to load and release of the modified layer for aspirin.

Related Topics
Physical Sciences and Engineering Chemical Engineering Colloid and Surface Chemistry
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