Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6027776 | NeuroImage | 2014 | 35 Pages |
Abstract
Longitudinal VBM demonstrated that the progression of GM atrophy in PPMS occurs at different rates in different regions across the brain. The involvement of the cingulate cortex occurs early in the disease course, continues at a steady rate throughout the follow-up period and is associated with patient outcome. These findings provide new insights into the characteristics of GM atrophy across the brain in MS, and have potential consequences for the selection of brain atrophy as an outcome measure in neuroprotective clinical trials.
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Authors
Arman Eshaghi, Benedetta Bodini, Gerard R. Ridgway, Daniel GarcÃa-Lorenzo, Daniel J. Tozer, Mohammad Ali Sahraian, Alan J. Thompson, Olga Ciccarelli,