Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6028885 | NeuroImage | 2013 | 10 Pages |
Abstract
In conclusion we can state that in vivo imaging in PDE10A KO mice, rats and monkey demonstrates that [18F]JNJ42259152 provides a PDE10A-specific signal in the striatum with good pharmacokinetic properties. Although presence of a polar radiometabolite in rat brain yielded a systematic but reproducible underestimation of the striatal BPND, a Logan reference tissue model approach using 60Â min acquisition data is appropriate for quantification.
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Authors
S. Celen, M. Koole, M. Ooms, M. De Angelis, I. Sannen, J. Cornelis, J. Alcazar, M. Schmidt, A. Verbruggen, X. Langlois, K. Van Laere, J.I. Andrés, G. Bormans,