| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6028901 | NeuroImage | 2013 | 8 Pages |
Abstract
FA was optimally predicted (based on the highest false discovery rate critical p), by five SNPs (rs1017412, rs2114252, rs16941261, rs3784406, and rs7176429; overall FDR critical p = 0.028). Gene effects were widespread and included the corpus callosum genu and inferior longitudinal fasciculus - regions implicated in several neuropsychiatric disorders and previously associated with other neurotrophin-related genetic variants in an overlapping sample of subjects. NTRK3 genetic variants, and neurotrophins more generally, may influence white matter integrity in brain regions implicated in neuropsychiatric disorders.
Keywords
BPDNTRK1FDRDTIIFOMAFOCDNT3HWEFWHMBDNFbipolar disorderObsessive–compulsive disorderSchizophreniaDizygoticinferior fronto-occipital fasciculusdiffusion tensor imagingHardy–Weinberg equilibriumFLIRTLinkage disequilibriumfull-width at half maximumBrain-derived neurotrophic factorminor allele frequenciesMonozygoticfalse discovery ratefractional anisotropySingle nucleotide polymorphismSNP
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Authors
Meredith N. Braskie, Omid Kohannim, Neda Jahanshad, Ming-Chang Chiang, Marina Barysheva, Arthur W. Toga, John M. Ringman, Grant W. Montgomery, Katie L. McMahon, Greig I. de Zubicaray, Nicholas G. Martin, Margaret J. Wright, Paul M. Thompson,