Intrinsic variability in the human response to pain is assembled from multiple, dynamic brain processes

► EEG-fMRI study of the origins of inter- and intra-subject pain response variability ► Single-trial correlation between BOLD and evoked potential responses and pain ratings ► Pre-stimulus DMN activity modulates subsequent pain ratings, BOLD and EEG responses. ► CHEPs and DMN response to pain stimulation is modulated by ongoing EEG alpha power. ► Pain network BOLD response to pain is predicted by the network's resting connectivity.