Neuronal correlates of the five factor model (FFM) of human personality: Multimodal imaging in a large healthy sample

► Neuroticism was the NEO-PI trait most clearly linked to brain structure. ► Higher neuroticism was associated with smaller total brain volume. ► Higher neuroticism was associated with reduced frontotemporal surface area. ► Neuroticism was associated with widespread decrease in white matter microstructure. ► Multimodal imaging promising in delineating the neural substrate of personality.