Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
603009 | Colloids and Surfaces B: Biointerfaces | 2007 | 5 Pages |
Abstract
The tri-headed anionic dendritic amphiphile, 4-(2-carboxyethyl)-4-[(icosyloxycarbonyl)amino]heptanedioic acid (3CCb20), forms mixed aggregates with dipalmitoylphosphatidylcholine (DPPC) in excess water at 3CCb20:DPPC = 0.91:1 molar ratio. On heating, these mixed aggregates transform into fluid bilayers stacked in the liquid crystalline lamellar Lα phase at about 40 °C. This phase transition and the microstructure of 3CCb20 + DPPC aggregates were studied with small- and wide-angle synchrotron X-ray diffraction. The ability of 3CCb20 to solubilize solidlike lipid bilayers could contribute to the antimicrobial activities of 3CCb20, including its anti-HIV activity.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Colloid and Surface Chemistry
Authors
Janka Karlovská, André A. Williams, Richard V. Macri, Richard D. Gandour, Sérgio S. Funari, Daniela Uhríková, Pavol Balgavý,