Linear intensity normalization of FP-CIT SPECT brain images using the α-stable distribution

► A linear procedure for intensity normalization using an α-stable distribution. ► α-stable parameters are estimated using the Maximum-Likelihood method. ► Location-scale property is used to linearly transform the voxel intensity values. ► The proposed method is compared with the widely used specific-to-non specific ratio. ► Intersubject differences in the non-specific regions are reduced.