| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6030164 | NeuroImage | 2013 | 12 Pages |
Abstract
⺠Numerous effects of halogenated anesthetics detected in the intact brain by 1H MRS ⺠Isoflurane regioselectively caused major rapidly reversible rise in brain lactate. ⺠Brain lactate correlated with concentration and potency of the halogenated agents. ⺠Most of isoflurane effects were attenuated by antiadrenergic drugs. ⺠Metabolic alterations by isoflurane need consideration in functional neuroimaging.
Keywords
INSFluorodesoxyglucosePDHminimal alveolar concentrationGLNN-acetylaspartateFDGADPALAMRSTCrTCANaAcAMPAdenosine TriphosphateATPadenosine diphosphateCyclic adenosine monophosphatealanineγ-aminobutyric acidChoAnesthesiaTaurinecholine-containing compoundsTauCNSBrain metabolismcentral nervous systemphosphatidylinositolLactateCerebrospinal fluidCSFMACMyo-inositolpyruvate dehydrogenasetricarboxylic acid cycleHVAGABAGluglutamateglutamine
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Authors
Susann Boretius, Roland Tammer, Thomas Michaelis, Jürgen Brockmöller, Jens Frahm,