The intrinsic connectivity distribution: A novel contrast measure reflecting voxel level functional connectivity

► We devised a novel metric to detect differences in functional connectivity. ► Intrinsic Connectivity Distribution (ICD) models voxel connection distributions. ► Unlike the network measure degree, ICD does not require a connection threshold. ► ICD is an exploratory tool that probes local tissue connectivity and organization. ► ICD revealed differences between preterm and term subjects not identified by degree.