fMRI response in the medial prefrontal cortex predicts cocaine but not sucrose self-administration history

► Systems-level investigation of neuroadaptations in a rodent addiction model. ► mPFC response correlates with the cocaine, but not sucrose intake history. ► Employing a cocaine SA and withdrawal model known to induce addiction-like behavior. ► Sucrose SA to control for non-specific contextual learning effects, motor behavior.