Neural substrates of normal and impaired preattentive sensory discrimination in large cohorts of nonpsychiatric subjects and schizophrenia patients as indexed by MMN and P3a change detection responses

► Large cohort of research participants (410 SZ patients, 247 NCS) ► MMN/P3a networks distributed across temporal, frontal, and parietal regions ► MMN deficits associated with reduced activation of discrete medial frontal regions ► P3a deficits associated with reductions in temporal, frontal, and parietal regions ► Results consistent with hierarchical “cascade” models of SZ deficits